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Cemal Cingi
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List of Archive

Volume 9, Issue 1, April 2019, Pages: 11-17

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How Do Histopathological Findings Relate To Cervical Lymph Node Metastasis In Laryngeal Cancer?
A Retrospective Study And Literature Review

Seyda Belli MD.1, Metin Yıldırım MD.2, Funda Emre Kaya MD.3, Tolga Bilece MD.4, Mehmet Faruk Oktay MD.5

1 Bagcilar Training and Research Hospital, Otorhinolaryngology Dept., Istanbul- Turkey - ORCID ID: 0000-0002-9132-4419
2 Gumushane State Hospital, Otorhinolaryngology Department, Istanbul- Turkey - ORCID ID: 0000-0002-0199-3556
3 Bagcilar Training and Research Hospital, Pathology Department, Istanbul- Turkey - ORCID ID: 0000-0002-8822-0723
4 Bakırkoy Training and Research Hospital, Otorhinolaryngology Department, Istanbul- Turkey - ORCID ID: 0000-0002-3755-9559
5 Bagcilar Training and Research Hospital, Otorhinolaryngology Dept., Istanbul- Turkey - ORCID ID: 0000-0001-5708-4813

 


Abstract

Purpose: This study aimed to elucidate how histopatho­logical findings relate to the existence of metastases in lymph nodes in a cohort of surgical cases with squamous cell carcinoma of the larynx.

Material and Methods: A cohort of cases from the ENT department, who had partial or total laryngectomy and dissection of the neck in the period spanning January 2008 to June 2017 were evaluated retrospectively. 150 cases were deemed appropriate for inclusion in the study. The histopathological notes and clinical findings of these cases were compared to each other.

Findings: The glottic group had lower levels of lympho­vascular invasion (p<0.05). Tumours staged at T3 or T4 level or endophytic in subtype were, however, more like­ly to have lymphovascular invasive features (p<0.05). For neoplasms with a high degree of differentiation, it was less frequent to observe invasion of lymphatics, metasta­sis to the cervical nodes or invasion beyond the capsule (p<0.05). Perineural invasion was not associated with a greater risk of the neoplasm metastasizing to the cervi­cal lymphovasculature, but invasion of the lymphatics did signal an increase in metastasis (p<0.05).

Conclusion: Cervical lymphatic metastasis of squamous cell carcinoma of the larynx has a high degree of correla­tion with histopathological grading.
Key Words: Laryngeal cancer, perineural invasion, lym­phovascular invasion, cervical lymphatic metastasis

 


Keywords

Laryngeal cancer, perineural invasion, lymphovascular invasion


 

 

 

 

 

 

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