entupdates cover page
e-ISSN:2149-6498
Editor-in-Chief
Cemal Cingi
2020 Vol. 10
 
downicon 2020
»Volume: 10 Issue: 2
»Volume: 10 Issue: 1
downicon 2019
»Volume: 9 Issue: 3
»Volume: 9 Issue: 2
»Volume: 9 Issue: 1
downicon 2018
»Volume: 8 Issue: 3
»Volume: 8 Issue: 2
»Volume: 8 Issue: 1
downicon 2017
»Volume: 7 Issue: 3
»Volume: 7 Issue: 2
»Volume: 7 Issue: 1
downicon 2016
»Volume: 6 Issue: 3
»Volume: 6 Issue: 2
»Volume: 6 Issue: 1
downicon 2015
»Volume: 5 Issue: 3
»Volume: 5 Issue: 2
»Volume: 5 Issue: 1
 
List of Archive

Volume 9, Issue 1, April 2019, Pages: 44-52

icon2 PDF (584 KB)

Correlation of Histopathological Findings in Laryngeal Squamous Cell Carcinoma with Inflammatory Biomarkers

Ildem Deveci MD1, Mehmet Surmeli MD2, Serap Onder MD3, Burak Karabulut MD4, Hande Senem Deveci MD5, Cagatay Oysu MD6

1Health Science University Umraniye Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey ORCID ID: 0000-0002-1573-8345
2Health Science University Umraniye Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey ORCID ID: 0000-0002-7936-2957
3Health Science University Umraniye Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey ORCID ID: 0000-0002-3576-0953
4Health Science University Umraniye Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey ORCID ID: 0000-0002-3958-3683
5Health Science University Fatih Sultan Mehmet Education and Research Hospital, Department of Otorhinolaryngology, Istanbul Turkey ORCID ID: 0000-0002-0836-7566
6Marmara University, Department of Otorhinolaryngology, Istanbul Turkey ORCID ID: 0000-0002-6756-8456

 


Abstract

Objective: The goal of this research was to investigate how biomarkers, i.e. SII (an index calculated from blood counts of various leucocytes), NLR and MLR correlate with features used in the staging of laryngeal squamous cell carcinoma (LSCC), i.e. perineural infiltration, lymphatic involvement and histological grade.

Methods:A retrospective review of clinical records from 146 cases (143 men and 3 women) of LSCC occurring between January 2008 and January 2018 was undertaken. The sample included every stage of LSCC and all biomarker results were found from the full blood count (FBC) results obtained prior to surgery and documented for each case. SII is a newly introduced index of inflammation calculated according to the formula: SII = NxP/L, where N represents neutrophil, P platelet and L lymphocyte counts.  Histopathological parameters (presence of perineural or lymphatic involvement, grade of tumour) were evaluated alongside results for NLR, MLR and SII.

Results:All three biomarkers were different at the level of statistical significance between individuals with LSCC and the controls. For NLR, p=0.003; for MLR, p=0.008; for SII, p<0.001. Both NLR and SII were different at a statistically significant level when compared at early and advanced stages of LSCC (p values were 0.011 and <0.001, respectively. MLR did not differ at the level of statistical significance (p=0.944). (See Table 3).

Conclusion:SII is straightforward to calculate, economical and reproducible from FBC results. It can provide important clues to the likelihood of perineural or lymphatic involvement in cases of LSCC.

 


Keywords

Laryngeal squamous cell carcinoma, inflammatory biomarkers


 

 

 

 

 

 

EndNote Style
Click to download the EndNote style of our journal ENT Updates to format your references.

Your Opinions are Important to Us! 
We are waiting for your valuable opinions and contributions...

Open Access
Our journal promotes the development of global open access to scientific information and research...

ESCI
ulakbim
doaj
proquest
ebsco
google scholar